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VIP (Vasoactive Intestinal Peptide) 5mg

Neuropeptide & Immunomodulatory Regulator

$60.00$45.00

Grade: Research Grade / Analytical Standard

Purity: ≥99% (HPLC Verified)

Format: Lyophilized (Freeze-Dried) Powder

Unit Size: 5 mg

Product Overview

VIP 5mg (Vasoactive Intestinal Peptide) is a naturally occurring 28-amino acid neuropeptide that plays a fundamental role in neuroendocrine signaling, smooth muscle relaxation, and systemic immune regulation. Acting as a potent high-affinity agonist at VPAC1 and VPAC2 G-protein coupled receptors, VIP is widely studied for its ability to modulate cytokine expression, regulate pulmonary arterial tone, and preserve mucosal tissue integrity under inflammatory stress.

This 5mg format provides research laboratories with an optimal, highly stable unit for baseline receptor profiling, anti-inflammatory signaling assays, and microvascular reactivity studies.

Key Research Features & Highlights

  • High-Affinity VPAC1 & VPAC2 Agonism: Engages primary VPAC receptor subtypes to trigger intracellular cAMP accumulation and downstream immunomodulatory pathways.

  • Potent Anti-Inflammatory Signaling: Widely referenced in literature for inhibiting pro-inflammatory cytokines (such as TNF-α, IL-6, and IL-12) while promoting anti-inflammatory IL-10 production.

  • Vascular & Smooth Muscle Dynamics: Serves as a primary reference tool for evaluating non-adrenergic, non-cholinergic (NANC) vasodilation and pulmonary vascular resistance.

  • Analytical Grade Purity (≥99%): Independently validated via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee high batch-to-batch repeatability.

Primary Applications in Laboratory Research

  • Immunomodulation & Cytokine Balance: Investigating T-cell differentiation, macrophage activation, and immune tolerance cascades in inflammatory disease models.

  • Pulmonary & Cardioprotective Research: Analyzing pulmonary vascular remodeling, airway smooth muscle relaxation, and microvascular perfusion.

  • Neuroprotection & CNS Signaling: Studying neuroinflammatory suppression, glial cell survival, and neurotrophic factor regulation.

  • Gastrointestinal Barrier Function: Evaluating epithelial cell tight-junction integrity, mucosal secretion, and gut-brain axis signaling.

Product Specifications

Attribute

Specification

Active Compound

Vasoactive Intestinal Peptide (VIP)

Net Quantity

5 mg

Form

Lyophilized White Powder

CAS Number

40077-57-4

Molecular Mass

~3325.80 g/mol

Sequence

His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2

Purity Standard

≥99% (HPLC verified)

Solubility

Soluble in Bacteriostatic Water or Sterile Deionized Water

Storage & Handling Protocols

  • Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat and UV light exposure.

  • Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water) and utilize within 30 days. Avoid repeated freeze-thaw cycles.

Mandatory Research & Legal Disclaimer

FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory application. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, or commercial drug formulation.