TB-500 10mg
Synthetic Thymosin Beta-4 Fragment
$65.00$45.00
Grade: Research Grade / Analytical Standard
Purity: ≥99% (HPLC Verified)
Format: Lyophilized (Freeze-Dried) Powder
Unit Size: 10 mg
Product Overview
TB-500 10mg is a high-purity synthetic peptide corresponding to the active region of Thymosin Beta-4 (Tβ4), a naturally occurring peptide present in high concentrations in blood platelets, wound fluid, and tissue structures. TB-500 is extensively studied in regenerative biology for its low molecular weight, high tissue permeability, and critical role in actin sequestration, cell migration, and tissue remodeling.
This 10mg high-yield format provides research facilities with an optimal concentration for multi-run cell culture assays, actin polymerization dynamics, and vascular cell migration studies.
Key Research Features & Highlights
Actin Cytoskeletal Regulation: Serves as a primary reference tool for evaluating actin sequestration (G-actin monomer binding), cell motility, and structural cell remodeling.
Pro-Angiogenic & Endothelial Migration: Widely utilized to analyze microvascular cell growth, capillary tube formation, and new blood vessel development.
Enhanced Tissue Permeability: Features a low molecular mass that allows rapid diffusion through extracellular matrix structures during in vitro tissue assays.
Analytical Purity (≥99%): Standardized and batch-tested using High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee high experimental reproducibility.
Primary Applications in Laboratory Research
Cell Motility & Wound Healing Models: Investigating dermal fibroblast, keratinocyte, and endothelial cell migration toward sites of simulated tissue injury.
Musculoskeletal & Tendon Remodeling: Studying collagen organization, myofibril repair, and extracellular matrix (ECM) restoration following cellular stress.
Cardiovascular & Tissue Preservation: Evaluating cytoprotective signaling pathways in cardiac and endothelial tissue models.
Anti-Inflammatory Signaling Cascades: Researching down-regulation of pro-inflammatory cytokines and nuclear factor kappa B (NF-κB) pathways.
Product Specifications
Attribute | Specification |
Active Compound | TB-500 (Thymosin Beta-4 Active Fragment) |
Net Quantity | 10 mg |
Form | Lyophilized White Powder |
CAS Number | 77591-33-4 |
Molecular Mass | ~4963.50 g/mol |
Sequence | Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH |
Purity Standard | ≥99% (HPLC verified) |
Solubility | Soluble in Bacteriostatic Water or Sterile Deionized Water |
Storage & Handling Protocols
Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat and UV light exposure.
Reconstituted Solution: Maintain at 2°C – 8°C after reconstituting with a sterile diluent (e.g., Bacteriostatic Water) and utilize within 30 days. Avoid repeated freeze-thaw cycles.
Mandatory Research & Legal Disclaimer
FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory application. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, or commercial drug formulation.