Sermorelin 10mg
Native-Sequence GHRH (1-29) Acetate / Pituitary Secretagogue Standard
$75.00$65.00
Grade: Research Grade / Analytical Standard
Purity: ≥99% (HPLC Verified)
Format: Lyophilized (Freeze-Dried) Powder
Unit Size: 10 mg
Product Overview
Sermorelin 10mg (GRF 1-29 Acetate) is a synthetic 29-amino acid polypeptide representing the fully functional truncated C-terminal sequence of naturally occurring Growth Hormone-Releasing Hormone (GHRH 1-44). Recognized as the shortest synthetic fragment capable of full GHRH receptor activation, Sermorelin binds specifically to somatotroph receptors in the anterior pituitary gland to stimulate the endogenous synthesis and secretion of growth hormone (GH).
Because Sermorelin operates through native somatotropic feedback loops—subject to natural somatostatin regulation—it preserves physiological, pulsatile GH release patterns. This high-capacity 10mg format provides research laboratories with an essential standard for evaluating pituitary somatotroph reserve capacity, somatotrophic axis dynamics, downstream IGF-1 expression, and metabolic cellular repair.
Key Research Features & Highlights
Functional GHRH Fragment (1-29): Contains the essential active amino acid chain required for binding and stimulating pituitary GHRH receptors.
Physiological Pulsatile GH Secretion: Stimulates endogenous growth hormone release governed by somatostatin feedback, preventing pituitary exhaustion or continuous over-stimulation.
High-Yield 10mg Capacity: Designed for extended experimental protocols, multi-run pulsatile assays, and high-throughput somatotropic research.
Downstream IGF-1 Axis Upregulation: Serves as a primary reference standard for studying systemic Insulin-like Growth Factor 1 elevation, nitrogen retention, and cellular anabolic repair cascades.
Analytical Grade Purity (≥99%): Independently batch-tested via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee high experimental repeatability.
Primary Applications in Laboratory Research
Pituitary Reserve & Receptor Kinetics: Investigating somatotroph GHRH receptor sensitivity, intracellular cAMP accumulation, and growth hormone secretion dynamics.
Protein Translation & Anabolic Pathways: Studying Akt/mTOR signaling activation, cellular hypertrophy, and amino acid transport in muscle tissue models.
Adipocyte Lipolysis & Metabolic Regulation: Researching lipid mobilization, fatty acid oxidation acceleration, and baseline metabolic rate shifts.
Extracellular Matrix & Tissue Repair: Evaluating collagen deposition, fibroblast migration, and bone density signaling pathways.
Product Specifications
Attribute | Specification |
Active Compound | Sermorelin Acetate (GRF 1-29 / GHRH 1-29) |
Net Quantity | 10 mg |
Form | Lyophilized White Powder |
CAS Number | 86168-78-7 |
Molecular Mass | ~3357.88 g/mol |
Sequence | Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 |
Purity Standard | ≥99% (HPLC verified) |
Solubility | Soluble in Bacteriostatic Water or Sterile Deionized Water |
Storage & Handling Protocols
Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat, light, and humidity.
Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water) and utilize within 30 days. Avoid repeated freeze-thaw cycles.
Mandatory Research & Legal Disclaimer
FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, cosmetic application, or commercial drug formulation.