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PT-141 10mg

Central Melanocortin Receptor Agonist / Bremelanotide Standard

$50.00$40.00

Grade: Research Grade / Analytical Standard

Purity: ≥99% (HPLC Verified)

Format: Lyophilized (Freeze-Dried) Powder

Unit Size: 10 mg

Product Overview

PT-141 10mg (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH), chemically known as Bremelanotide, is a synthetic cyclic heptapeptide and active metabolite of Melanotan-2 (MT-2). Unlike traditional compounds that target peripheral vascular mechanics, PT-141 acts as a potent, non-selective agonist at central nervous system Melanocortin Receptors, exhibiting high affinity for MC3R and MC4R located within hypothalamic neuronal circuits.

Because it bypasses vascular signaling to act directly on central neurogenic pathways, PT-141 serves as a vital reference compound in neurobiology for investigating central autonomic control, appetitive behaviors, neuro-endocrine signaling, and central melanocortin-mediated arousal mechanics.

Key Research Features & Highlights

  • Central Nervous System Agonism: Targets central hypothalamic MC3R and MC4R pathways to study central neuro-endocrine regulation without primary reliance on peripheral vascular nitric oxide pathways.

  • Cyclic Lactam Structure: Features a cyclic peptide core that provides superior enzymatic stability and prolonged operational half-life during in vitro and receptor binding assays.

  • Depigmented Melanocortin Profile: Exhibits minimal MC1R activity relative to its parent compound (MT-2), allowing isolated investigation of central behavioral signaling without confounding cutaneous melanogenesis.

  • Hypothalamic Circuit Mapping: Widely utilized to evaluate medial preoptic area (mPOA) neuronal firing, dopamine release kinetics, and central autonomic regulation.

  • Analytical Grade Purity (≥99%): Independently batch-tested via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee precise experimental control and batch reproducibility.

Primary Applications in Laboratory Research

  • Central Neurogenic Pathways: Investigating MC3R/MC4R-mediated signaling within the central nervous system and hypothalamic nucleus activation.

  • Neuro-Endocrine Signaling & Behavior: Researching central modulation of appetitive behavior, autonomic physiological responses, and dopamine release kinetics.

  • Vascular & Autonomic Cross-Talk: Studying the interaction between central melanocortin receptor activation and peripheral autonomic nervous system outputs.

  • Receptor Selectivity Studies: Evaluating comparative binding kinetics across MC1R through MC5R profiles to differentiate central versus peripheral melanocortin actions.

Product Specifications

Attribute

Specification

Active Compound

PT-141 (Bremelanotide / Cyclic α-MSH Metabolite)

Net Quantity

10 mg

Form

Lyophilized White Powder

CAS Number

189691-06-3

Molecular Mass

~1025.18 g/mol

Sequence

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH

Purity Standard

≥99% (HPLC verified)

Solubility

Soluble in Bacteriostatic Water, PBS, or Sterile Deionized Water

Storage & Handling Protocols

  • Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat, light, and thermal fluctuations.

  • Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water) and utilize within 30 days. Avoid repeated freeze-thaw cycles.

Mandatory Research & Legal Disclaimer

FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, cosmetic application, or commercial drug formulation.