MOTS-c 40mg
High-Capacity Mitochondrial-Derived Peptide / Metabolic Regulator
$120.00$105.00
Grade: Research Grade / Analytical Standard
Purity: ≥99% (HPLC Verified)
Format: Lyophilized (Freeze-Dried) Powder
Unit Size: 40 mg
Product Overview
MOTS-c 40mg (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a high-capacity unit of the 16-amino acid mitochondrial-derived peptide (MDP) engineered for high-throughput laboratory research into cellular metabolic control and retrograde nuclear signaling. Unique for its encoded origin within the mitochondrial genome, MOTS-c translocates to the cell nucleus during metabolic stress, where it interacts with master regulatory hubs—including AMPK (AMP-activated protein kinase) and Nrf2—to direct glucose clearance, fatty acid oxidation, and adaptive metabolic homeostasis.
This bulk 40mg format provides core facilities, institutional laboratories, and multi-protocol researchers with an optimal, cost-effective compound volume for extended cell culture assays, dose-response studies, and multi-run metabolic kinetic trials.
Key Research Features & Highlights
High-Yield 40mg Capacity: Designed for high-throughput screening, multi-target cellular assays, and extended experimental timelines without frequent batch swapping.
Mitochondrial Genomic Origin: Serves as a primary reference standard for studying retrograde mitochondrial-to-nuclear signaling and nuclear chromatin interaction.
AMPK Pathway Activation: Widely studied for stimulating intracellular AMPK phosphorylation to enhance glucose uptake, lipid oxidation, and cellular bioenergetics.
Insulin Sensitivity & Metabolic Flexibility: Tailored for evaluating insulin receptor signaling enhancement, systemic glucose clearance, and skeletal muscle energy expenditure.
Analytical Grade Purity (≥99%): Independently batch-tested via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee precise experimental control and reproducibility.
Primary Applications in Laboratory Research
High-Volume Mitochondrial Bioenergetics: Investigating age-related declines in cellular energy flux, mitochondrial respiration rates, and NAD+/NADH dynamics at scale.
Glucose Homeostasis & Insulin Resistance: Studying skeletal muscle glucose transporter (GLUT4) translocation and lipid clearance mechanisms under simulated metabolic stress.
Exercise Mimetic Signaling: Researching endurance performance pathways, exercise-induced metabolic adaptations, and lactate turnover in cell models.
Cytoprotection & Stress Response: Analyzing cellular survival mechanisms under nutrient deprivation, oxidative stress, and metabolic dysfunction.
Product Specifications
Attribute | Specification |
Active Compound | MOTS-c (Mitochondrial ORF of 12S rRNA c) |
Net Quantity | 40 mg |
Form | Lyophilized White Powder |
CAS Number | 1627580-64-6 |
Molecular Mass | ~2174.60 g/mol |
Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
Purity Standard | ≥99% (HPLC verified) |
Solubility | Soluble in Bacteriostatic Water or Sterile Deionized Water |
Storage & Handling Protocols
Unreconsolidated (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from thermal fluctuations and humidity.
Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water) and utilize within research protocol parameters. Avoid repeated freeze-thaw cycles.
Mandatory Research & Legal Disclaimer
FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, or commercial drug formulation.