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MOTS-c 10mg

Mitochondrial-Derived Peptide / Metabolic Regulator

$50.00$35.00

Grade: Research Grade / Analytical Standard

Purity: ≥99% (HPLC Verified)

Format: Lyophilized (Freeze-Dried) Powder

Unit Size: 10 mg

Product Overview

MOTS-c 10mg (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino acid mitochondrial-derived peptide (MDP) that acts as a signaling molecule regulating metabolic homeostasis and nuclear gene expression. Unique among peptides for its origin within the mitochondrial genome, MOTS-c translocates to the nucleus during cellular metabolic stress, where it interacts with key metabolic regulators like AMPK (AMP-activated protein kinase) and Nrf2 to regulate insulin sensitivity, glucose utilization, and cellular energy balance.

This 10mg format provides research laboratories with an optimal unit for conducting cellular metabolic assays, mitochondrial bioenergetic studies, and exercise-mimetic pathways research.

Key Research Features & Highlights

  • Mitochondrial Genomic Origin: Serves as a primary reference tool for studying retrograde mitochondrial-to-nuclear signaling and nuclear chromatin interaction.

  • AMPK Pathway Activation: Widely studied for stimulating intracellular AMPK phosphorylation to promote glucose uptake, lipid oxidation, and cellular energy flux.

  • Insulin Sensitivity & Metabolic Flexibility: Tailored for evaluating insulin receptor signaling enhancement, systemic glucose clearance, and skeletal muscle metabolism.

  • Analytical Grade Purity (≥99%): Standardized and batch-tested using High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee high experimental repeatability.

Primary Applications in Laboratory Research

  • Mitochondrial Bioenergetics & Aging: Investigating age-related decline in cellular energy expenditure, mitochondrial respiration, and NAD+/NADH dynamics.

  • Glucose Homeostasis & Insulin Resistance: Studying skeletal muscle glucose transporter (GLUT4) translocation and lipid clearance in metabolic stress models.

  • Exercise Mimetic Signaling: Researching endurance performance pathways, exercise-induced metabolic adaptations, and lactate turnover.

  • Cytoprotection & Stress Response: Analyzing cellular survival mechanisms under nutrient deprivation, oxidative stress, and metabolic dysfunction.

Product Specifications

Attribute

Specification

Active Compound

MOTS-c (Mitochondrial ORF of 12S rRNA c)

Net Quantity

10 mg

Form

Lyophilized White Powder

CAS Number

1627580-64-6

Molecular Mass

~2174.60 g/mol

Sequence

Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Purity Standard

≥99% (HPLC verified)

Solubility

Soluble in Bacteriostatic Water or Sterile Deionized Water

Storage & Handling Protocols

  • Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from thermal fluctuations and moisture.

  • Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water) and utilize within 30 days. Avoid repeated freeze-thaw cycles.

Mandatory Research & Legal Disclaimer

FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, or commercial drug formulation.