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Melanotan-2 (MT-2) 10mg

Non-Selective Melanocortin Receptor Agonist / Synthetic α-MSH Analogue

$55.00$45.00

Grade: Research Grade / Analytical Standard

Purity: ≥99% (HPLC Verified)

Format: Lyophilized (Freeze-Dried) Powder

Unit Size: 10 mg

Product Overview

Melanotan-2 (MT-2) 10mg (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2) is a synthetic cyclic heptapeptide analogue of naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). Chemically engineered with a lactam bridge between Asp2 and Lys7, MT-2 exhibits exceptional conformational stability, prolonged biological half-life, and potent non-selective agonist binding across central and peripheral melanocortin receptors (MC1R, MC3R, MC4R, and MC5R).

In scientific research, MT-2 serves as a multi-target reference standard for studying cutaneous melanogenesis (MC1R stimulation), central regulation of sexual behavior and erectile mechanics (MC3R/MC4R activation), lipid clearance, and hypothalamic energy homeostasis.

Key Research Features & Highlights

  • Multi-Receptor Non-Selective Agonist: Binds with high affinity to MC1R, MC3R, MC4R, and MC5R, allowing comprehensive multi-systemic signaling research.

  • Cyclic Structural Stability: Engineered with a lactam ring closure that prevents rapid enzymatic cleavage by peptidases and significantly extends half-life during in vitro assays.

  • Potent Melanogenesis Stimulation: Serves as a primary reference tool for evaluating tyrosinase activation, melanocyte proliferation, and eumelanin synthesis in epidermal cell models.

  • Central & Peripheral Systemic Binding: Extensively studied in neuroendocrine research for central nervous system-mediated pathways, including appetitive behaviors and hypothalamic metabolic signaling.

  • Analytical Grade Purity (≥99%): Independently validated via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee high batch-to-batch repeatability.

Primary Applications in Laboratory Research

  • Cutaneous Melanogenesis & Pigmentation Kinetics: Investigating intracellular cAMP elevation, melanosome transfer, and UV-independent melanin production in skin cell lines.

  • Central Neuroendocrine & Metabolic Signaling: Analyzing MC4R-mediated energy balance, satiety signaling, and basal metabolic expenditure regulation.

  • Sexual Behavior & Vascular Physiology: Researching central melanocortin pathway activation regarding smooth muscle relaxation and neurogenic arousal mechanisms.

  • Melanocortin Receptor Subtype Mapping: Evaluating competitive ligand binding, signal transduction pathways, and receptor desensitization across MC1R–MC5R profiles.

Product Specifications

Attribute

Specification

Active Compound

Melanotan-2 (MT-2 / Cyclic α-MSH Analogue)

Net Quantity

10 mg

Form

Lyophilized White Powder

CAS Number

121062-08-6

Molecular Mass

~1024.18 g/mol

Sequence

Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Purity Standard

≥99% (HPLC verified)

Solubility

Soluble in Bacteriostatic Water, PBS, or Sterile Deionized Water

Storage & Handling Protocols

  • Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat, direct UV light, and humidity.

  • Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water) and utilize within 30 days. Protect reconstituted solution from light and avoid repeated freeze-thaw cycles.

Mandatory Research & Legal Disclaimer

FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, cosmetic application, or commercial drug formulation.