Melanotan-1 10mg

Grade: Research Grade / Analytical Standard

Purity: ≥99% (HPLC Verified)

Format: Lyophilized (Freeze-Dried) Powder

Unit Size: 10 mg

Product Overview

Melanotan-1 10mg (Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2), also known as Afamelanotide, is a synthetic 13-amino acid peptide analogue of naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). Specifically engineered with a substituted Nle4 and D-Phe7 modification, Melanotan-1 exhibits enhanced resistance to enzymatic cleavage and high affinity for the Melanocortin-1 Receptor (MC1R).

Unlike non-selective melanocortin agonists, Melanotan-1 acts as a potent, linear agonist primarily targeting cutaneous melanocytes. It serves as a vital reference compound in dermatological research for investigating eumelanin biogenesis, cellular photoprotection against ultraviolet (UV) radiation, and neuro-immunomodulatory melanocortin signaling cascades without causing central nervous system-mediated side effects.

Key Research Features & Highlights

• Selective MC1R Binding: Demonstrates high receptor specificity for MC1R located on epidermal melanocytes, driving targeted melanin pigment synthesis.

• Photoprotection & DNA Repair Signaling: Widely studied for its ability to stimulate protective eumelanin production, reduce UV-induced thymine dimer formation, and accelerate DNA damage repair mechanisms.

• Enzymatic Stability (Nle4, D-Phe7 Modification): Features amino acid substitutions designed to resist rapid peptidase breakdown, providing extended active half-life during in vitro assays.

• Anti-Inflammatory & Cytoprotective Properties: Serves as a primary reference tool for evaluating melanocortin-mediated anti-inflammatory signaling, cytokine suppression, and vascular endothelial protection.

• Analytical Grade Purity (≥99%): Independently batch-tested via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure baseline repeatability and experiment consistency.

Primary Applications in Laboratory Research

• Cutaneous Melanogenesis Dynamics: Investigating intracellular cAMP pathway stimulation, tyrosinase activity, and eumelanin-to-pheomelanin ratio shifts in epidermal cell models.

• UV-Induced Stress & Photobiology: Researching cellular protection pathways against reactive oxygen species (ROS), oxidative stress, and UV radiation-induced apoptotic cascades.

• Melanocortin System Mapping: Evaluating receptor subtype selectivity (MC1R vs. MC3R/MC4R/MC5R) and intracellular secondary messenger signaling.

• Dermatological & Inflammatory Kinetics: Analyzing NF-κB pathway regulation, mast cell stabilization, and skin barrier maintenance under inflammatory challenge.

Product Specifications

Storage & Handling Protocols

• Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat, light, and humidity.

• Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water) and utilize within 30 days. Protect reconstituted solutions from direct light and avoid repeated freeze-thaw cycles.

Mandatory Research & Legal Disclaimer

FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, cosmetic application, or commercial drug formulation.