Mazdutide 10mg

Grade: Research Grade / Analytical Standard

Purity: ≥99% (HPLC Verified)

Format: Lyophilized (Freeze-Dried) Powder

Unit Size: 10 mg

Product Overview

Mazdutide 10mg (IBI362 / LY3305677) is a long-acting synthetic mammalian oxyntomodulin (OXM) analogue engineered for advanced laboratory research into dual-receptor metabolic regulation. Acting as a potent co-agonist at both the Glucagon-Like Peptide-1 Receptor (GLP-1R) and the Glucagon Receptor (GCGR), Mazdutide mimics native oxyntomodulin signaling to regulate glycemic control, appetite suppression, and hepatic energy expenditure.

This 10mg high-yield format provides research facilities with an optimal volume for conducting multi-run metabolic assays, lipid turnover studies, and comparative co-agonist profiling against single-target incretin mimetics.

Key Research Features & Highlights

• Dual GLP-1R & GCGR Co-Agonism: Uniquely engages both GLP-1 and glucagon receptors, balancing insulinotropic satiety mechanisms with glucagon-mediated energy expenditure.

• Engineered Extended Stability: Features a fatty acid side chain (C20 fatty diacid moiety) that enhances plasma protein binding, extending plasma half-life for extended analytical protocols.

• Hepatic Lipid & Energy Expenditure Focus: Serves as a primary reference tool for analyzing liver fat content clearance, basal metabolic rate acceleration, and lipid turnover.

• Analytical Grade Purity (≥99%): Independently validated via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee high batch-to-batch repeatability.

Primary Applications in Laboratory Research

• Co-Agonist Receptor Kinetics: Investigating differential activation ratios between GLP-1R and GCGR in metabolic tissue models.

• Hepatic Steatosis & Lipid Remodeling: Analyzing intrahepatic lipid accumulation, fatty acid oxidation, and liver biomarker dynamics.

• Energy Expenditure & Thermogenesis: Researching energy balance dynamics, brown adipose tissue activation, and weight regulation cascades.

• Glycemic & Pancreatic Beta-Cell Signaling: Studying glucose-dependent insulin secretion alongside counter-regulatory glucagon pathway dynamics.

Product Specifications

Storage & Handling Protocols

• Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat and light exposure.

• Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent and utilize within 30 days. Avoid repeated freeze-thaw cycles.