KPV 10mg

Grade: Research Grade / Analytical Standard

Purity: ≥99% (HPLC Verified)

Format: Lyophilized (Freeze-Dried) Powder

Unit Size: 10 mg

Product Overview

KPV 10mg (Lysine-Proline-Valine) is a potent, naturally occurring tripeptide fragment derived from the C-terminal region of alpha-melanocyte-stimulating hormone (α-MSH). Renowned in immunobiology for its remarkable anti-inflammatory efficacy, KPV acts as a targeted regulatory agent that preserves the potent anti-inflammatory properties of native α-MSH without activating melanogenic (pigmentation) or central appetite pathways.

KPV exerts its primary mechanisms by interacting with intracellular signaling networks to downregulate NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) activation, inhibiting nuclear translocation of pro-inflammatory transcription factors, and stabilizing mast cells. This 10mg format provides research facilities with a high-purity standard ideal for investigating gut mucosal preservation, intestinal epithelial barrier restoration, and cutaneous inflammatory suppression.

Key Research Features & Highlights

• Targeted NF-κB Pathway Suppression: Serves as a primary reference tool for analyzing the inhibition of pro-inflammatory nuclear factor kappa B signaling and downstream cytokine cascades (TNF-α, IL-6, IL-1β).

• Mucosal & Epithelial Barrier Integrity: Widely studied in gastrointestinal and dermatological research models for accelerating mucosal healing and maintaining tight junction protein alignment (Claudin, Occludin).

• Non-Pigmentary α-MSH Derivative: Retains full immunomodulatory potency without binding cutaneous MC1R to induce melanogenesis, ensuring isolated anti-inflammatory experimental control.

• Mast Cell Stabilization & Antimicrobial Activity: Demonstrates intrinsic antimicrobial properties against pathogens such as Staphylococcus aureus and Candida albicans, alongside mast cell degranulation attenuation.

• Analytical Grade Purity (≥99%): Independently validated via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee high batch-to-batch repeatability.

Primary Applications in Laboratory Research

• Gastrointestinal & IBD Models: Investigating ulcerative colitis, Crohn's disease dynamics, gut microbiome homeostasis, and mucosal inflammation reduction in vitro.

• Dermatological & Wound Healing Dynamics: Studying psoriasis, eczema, contact dermatitis, and accelerated epidermal re-epithelialization in skin cell cultures.

• Cytokine Dynamics & Inflammatory Cascade Control: Evaluating the reduction of pro-inflammatory mediator expression in endotoxin-challenged or oxidative-stressed cell lines.

• Pathogen-Host Interaction Studies: Analyzing broad-spectrum antimicrobial activity and host defense peptide mechanics against common bacterial and fungal strains.

Product Specifications

Storage & Handling Protocols

• Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat, light, and humidity.

• Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water) and utilize within 30 days. Avoid repeated freeze-thaw cycles.

Mandatory Research & Legal Disclaimer

FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, cosmetic application, or commercial drug formulation.