Kisspeptin-10 10mg
Hypothalamic Met-Enkephalin Secretin Analogue / Kiss1r Agonist
$50.00$40.00
Grade: Research Grade / Analytical Standard
Purity: ≥99% (HPLC Verified)
Format: Lyophilized (Freeze-Dried) Powder
Unit Size: 10 mg
Product Overview
Kisspeptin-10 10mg (YNWNSFGLRF-NH2) is a synthetic 10-amino acid decapeptide representing the active C-terminal catalytic cleavage fragment of the larger Kiss-1 gene product (metastin). Functioning as a high-affinity endogenous agonist at the G-protein coupled receptor Kiss1r (GPR54), Kisspeptin-10 serves as the primary master regulator governing the hypothalamic-pituitary-gonadal (HPG) axis.
By directly stimulating gonadotropin-releasing hormone (GnRH) release within the arcuate and anteroventral periventricular nuclei, Kisspeptin-10 triggers downstream secretion of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). This high-capacity 10mg format provides research laboratories with an essential standard for evaluating GnRH pulse generator dynamics, reproductive endocrinology, central neuro-endocrine regulation, and tumor metastasis suppression in cell culture models.
Key Research Features & Highlights
High-Affinity Kiss1r (GPR54) Binding: Directly engages Kiss1r to activate the Gαq/11-phospholipase C (PLC) intracellular pathway, driving rapid inositol trisphosphate (IP3) generation and intracellular calcium mobilization.
Upstream HPG Axis Master Activation: Operates directly upstream of GnRH neurons to stimulate pulsatile Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) secretion.
Tumor Metastasis Suppression Mechanics: Extensively researched in oncology models for suppressing cellular motility, invasion, and metastatic cascade signaling (metastin activity).
Limond / Neuro-Endocrine Signaling Reference: Serves as a vital tool for studying metabolic status sensing, energy balance integration, and reproductive hormone interplay.
Analytical Grade Purity (≥99%): Independently batch-tested via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee precise experimental baseline control and batch reproducibility.
Primary Applications in Laboratory Research
HPG Axis & GnRH Pulsatility Kinetics: Investigating hypothalamic GnRH neuronal firing rates, LH/FSH pulse amplitude modifications, and neuroendocrine feedforward loops.
Kiss1r Receptor Signaling & Intracellular Calcium Flux: Studying GPR54 desensitization, internalizing mechanics, and secondary messenger cascades in endocrine cell lines.
Oncology & Anti-Metastatic Pathways: Evaluating metastatic cell migration inhibition, matrix metalloproteinase (MMP) down-regulation, and tumor microenvironment interaction.
Metabolic-Reproductive Cross-Talk: Researching how metabolic signals (leptin, ghrelin, insulin) modulate Kiss-1 gene expression and reproductive capability.
Product Specifications
Attribute | Specification |
Active Compound | Kisspeptin-10 (Kiss1 Fragment 112-121 / Metastin 45-54) |
Net Quantity | 10 mg |
Form | Lyophilized White Powder |
CAS Number | 374675-21-5 |
Molecular Mass | ~1302.45 g/mol |
Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
Purity Standard | ≥99% (HPLC verified) |
Solubility | Soluble in Water, PBS, or Sterile Deionized Water |
Storage & Handling Protocols
Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat, light, and humidity.
Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water or PBS) and utilize within 30 days. Avoid repeated freeze-thaw cycles.
Mandatory Research & Legal Disclaimer
FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, cosmetic application, or commercial drug formulation.