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IGF-1 LR3 1mg

Extended-Duration Insulin-like Growth Factor-1 Analogue

$75.00$55.00

Grade: Research Grade / Analytical Standard

Purity: ≥99% (HPLC Verified)

Format: Lyophilized (Freeze-Dried) Powder

Unit Size: 1 mg

Product Overview

IGF-1 LR3 1mg (Long Arginine 3 Insulin-like Growth Factor-1) is a synthetic 83-amino acid recombinant analogue of human IGF-1, engineered specifically for extended operational stability in laboratory research. Featuring an arginine substitution at position 3 and a 13-amino acid N-terminal extension sequence, IGF-1 LR3 exhibits significantly reduced affinity for IGF-binding proteins (IGFBPs). This structural alteration prevents rapid binding clearance, dramatically extending its biological half-life compared to native IGF-1.

This 1mg format provides research laboratories with an optimal standard for evaluating Akt/mTOR pathway activation, myoblast proliferation and differentiation, cellular hyperplasia, and glucose transport dynamics in cell-culture models.

Key Research Features & Highlights

  • IGFBP Resistance: Engineered to bypass IGF-binding protein inhibition, ensuring high free-concentration availability for receptor binding assays.

  • Extended Half-Life: Maintains prolonged receptor activity (~20–30 hours relative to native IGF-1’s short clearance duration) for extended cell line trials.

  • Potent Akt/mTOR Cascade Activation: Serves as a primary reference tool for analyzing intracellular signal transduction governing cellular growth, protein synthesis, and anti-apoptotic pathways.

  • Hyperplasia & Satellite Cell Activation: Widely utilized to study skeletal muscle satellite cell proliferation, myotube hypertrophy, and tissue repair kinetics.

  • Analytical Grade Purity (≥99%): Independently validated via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee high batch-to-batch repeatability.

Primary Applications in Laboratory Research

  • Muscle & Tissue Hypertrophy Signaling: Investigating satellite cell recruitment, protein translation mechanisms, and myoblast maturation in skeletal muscle models.

  • Cell Proliferation & Apoptosis Modulation: Researching cellular survival pathways, mitotic rate acceleration, and anti-apoptotic gene expression in culture.

  • Glucose Transport & Nutrient Uptake: Studying insulin-mimetic activity, intracellular GLUT4 translocation, and cellular amino acid uptake mechanics.

  • Cartilage & Bone Matrix Synthesis: Evaluating chondrocyte expansion, extracellular matrix production, and osteogenic differentiation cascades.

Product Specifications

Attribute

Specification

Active Compound

IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1)

Net Quantity

1 mg

Form

Lyophilized White Powder

CAS Number

946870-92-4

Molecular Mass

~9111.00 g/mol

Sequence

MFPAMPLSSL FVNGPRTLCG AELVDALQF VCGDRGFYFN KPTGYGSSSR RAPQTGIVDE CCFRSCDLRR LEMYCAPLK PAKSA

Purity Standard

≥99% (HPLC verified)

Solubility

Soluble in 0.1M Acetic Acid or Bacteriostatic Water

Storage & Handling Protocols

  • Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat, light, and thermal fluctuation.

  • Reconstituted Solution: Maintain at 2°C – 8°C following initial dilution (often requiring an acidic buffer like 0.1M Acetic Acid for primary dissolution prior to further dilution) and utilize within 30 days. Avoid repeated freeze-thaw cycles.

Mandatory Research & Legal Disclaimer

FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, or commercial drug formulation.