Glutathione 1500mg
Master Antioxidant Standard / Endogenous Redox & Detoxification Regulator
$89.99$79.99
Grade: Research Grade / Analytical Standard
Purity: ≥99% (HPLC Verified)
Format: Lyophilized (Freeze-Dried) Powder
Unit Size: 1500 mg
Product Overview
Glutathione 1500mg (γ-L-Glutamyl-L-cysteinylglycine / GSH) is a high-purity endogenous tripeptide composed of glutamate, cysteine, and glycine. Recognized across cellular biology as the primary master antioxidant, Glutathione acts as a major intracellular redox buffer, scavenging reactive oxygen species (ROS), neutralizing free radicals, and maintaining essential thiol status on cellular proteins.
Glutathione plays an indispensable role in Phase II hepatic detoxification, conjugating electrophilic toxins and heavy metals via Glutathione S-Transferase (GST) enzymes. This robust 1500mg bulk unit provides research facilities with an ideal standard for evaluating cellular stress responses, mitochondrial protection, detoxification pathways, and melanogenesis modulation in cultured cell lines.
Key Research Features & Highlights
High-Capacity 1500mg Unit: Engineered for high-throughput screening, multi-plate assays, and extended cellular protocol series requiring consistent, bulk substrate concentrations.
Master Intracellular Redox Buffer: Essential standard for measuring reduced-to-oxidized glutathione ratios (GSH/GSSG) to quantify cellular oxidative stress levels.
Phase II Enzymatic Conjugation: Serves as the primary cofactor for Glutathione S-Transferase (GST) and Glutathione Peroxidase (GPx) enzymatic neutralization kinetics.
Mitochondrial & Genomic Protection: Widely studied for safeguarding mitochondrial membrane integrity, lipid bilayers, and nuclear DNA from peroxide-induced damage.
Analytical Grade Purity (≥99%): Independently batch-tested via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure baseline consistency and protocol reproducibility.
Primary Applications in Laboratory Research
Oxidative Stress & ROS Scavenging Kinetics: Investigating intracellular free radical neutralization, peroxide breakdown, and cellular redox state maintenance.
Hepatic Phase II Detoxification Pathways: Evaluating GST-mediated conjugation mechanics, heavy metal chelation, and xenobiotic clearance in hepatocytes.
Cutaneous Melanogenesis Modulation: Researching the inhibition of tyrosinase activity and the metabolic shift from dark eumelanin to lighter pheomelanin synthesis in melanocyte cultures.
Mitochondrial Health & Apoptosis Regulation: Studying mitochondrial permeability transition pore (mPTP) stabilization and caspase activation suppression under oxidative challenge.
Product Specifications
Attribute | Specification |
Active Compound | L-Glutathione Reduced (GSH) |
Net Quantity | 1500 mg |
Form | Lyophilized White Powder |
CAS Number | 70-18-8 |
Molecular Mass | ~307.32 g/mol |
Sequence / Structure | γ-L-Glutamyl-L-cysteinylglycine |
Purity Standard | ≥99% (HPLC verified) |
Solubility | Highly soluble in Water, PBS, or Sterile Deionized Water |
Storage & Handling Protocols
Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat, light, and humidity.
Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Sterile Water for Injection or PBS) and utilize rapidly within protocol parameters, as aqueous glutathione is susceptible to oxidation over time. Avoid repeated freeze-thaw cycles.
Mandatory Research & Legal Disclaimer
FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, cosmetic application, or commercial drug formulation.