GHRP-6 5mg
Growth Hormone Releasing Hexapeptide / Ghrelin Receptor Agonist
$40.00$30.00
Grade: Research Grade / Analytical Standard
Purity: ≥99% (HPLC Verified)
Format: Lyophilized (Freeze-Dried) Powder
Unit Size: 5 mg
Product Overview
GHRP-6 5mg (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) is a synthetic hexapeptide Growth Hormone Secretagogue (GHS) and first-generation agonist of the Growth Hormone Secretagogue Receptor (GHS-R1a / Ghrelin Receptor). By binding to GHS-R1a on pituitary somatotrophs, GHRP-6 triggers potent, pulsatile releases of endogenous growth hormone (GH) while acting centrally within the hypothalamus to stimulate hunger signaling pathways and hyperphagic responses.
In laboratory research, GHRP-6 serves as a primary reference standard for studying GHS-R1a receptor binding kinetics, central appetite regulation via NPY/AgRP neurons, gastric motility, and cytoprotective mechanisms across cardiac and neural tissue cell lines.
Key Research Features & Highlights
Potent Pituitary GH Stimulation: Directly activates GHS-R1a receptors to induce rapid, high-amplitude bursts of endogenous growth hormone secretion.
Central Ghrelin Mimetic Action: Widely studied for its ability to cross the blood-brain barrier and stimulate hypothalamic appetite centers, making it a key standard in hyperphagia and metabolic research.
Gastric Motility Acceleration: Serves as an essential tool for evaluating ghrelin-mediated gastrointestinal smooth muscle contractions and gastric emptying kinetics.
Cardioprotective & Cytoprotective Signaling: Extensively researched in ischemic tissue models for suppressing apoptosis, reducing ROS-induced injury, and protecting cardiomyocytes.
Analytical Grade Purity (≥99%): Independently batch-tested via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure baseline consistency and protocol reproducibility.
Primary Applications in Laboratory Research
GHS-R1a Receptor Signaling & Calcium Flux: Investigating intracellular phospholipase C (PLC) activation, IP3 pathway cascades, and calcium ion influx in pituitary cells.
Central Appetite & Metabolic Pathway Research: Studying hypothalamic NPY/AgRP neuronal activation, energy balance regulation, and feeding behavior dynamics.
Tissue Ischemia & Cytoprotection: Researching anti-apoptotic pathways, mitochondrial membrane stabilization, and ischemic pre-conditioning kinetics in cardiac and neural tissue.
Gastrointestinal Physiology: Evaluating ghrelin-mediated enteric nervous system signaling and accelerated gut motility.
Product Specifications
Attribute | Specification |
Active Compound | GHRP-6 (Growth Hormone Releasing Hexapeptide) |
Net Quantity | 5 mg |
Form | Lyophilized White Powder |
CAS Number | 87616-84-0 |
Molecular Mass | ~873.01 g/mol |
Sequence | His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 |
Purity Standard | ≥99% (HPLC verified) |
Solubility | Soluble in Bacteriostatic Water or Sterile Deionized Water |
Storage & Handling Protocols
Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat, light, and thermal fluctuations.
Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water) and utilize within 30 days. Avoid repeated freeze-thaw cycles.
Mandatory Research & Legal Disclaimer
FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, cosmetic application, or commercial drug formulation.