Epithalon 10mg
Telomerase Activator Standard / Synthetic Epithalamin Analogue
$40.00$30.00
Grade: Research Grade / Analytical Standard
Purity: ≥99% (HPLC Verified)
Format: Lyophilized (Freeze-Dried) Powder
Unit Size: 10 mg
Product Overview
Epithalon 10mg (Ala-Glu-Asp-Gly), also known as Epitalon or Epithalone, is a synthetic tetrapeptide analogue of epithalamin, a peptide hormone naturally produced by the pineal gland. Renowned in biogerontology and molecular biology, Epithalon acts as a potent telomerase transcriptase activator, inducing the elongation of telomeric repeats at the terminal ends of eukaryotic chromosomes.
By restoring telomere length, Epithalon effectively overcomes the Hayflick limit in somatic cells, preventing premature replicative senescence. In cellular and endocrine research, Epithalon serves as a foundational reference tool for investigating epigenetic reprogramming, pineal gland homeostasis, melatonin synthesis normalization, and oxidative stress mitigation in aging cell lines.
Key Research Features & Highlights
Telomerase Transcriptase Upregulation: Serves as a primary reference standard for measuring telomerase catalytic subunit (TERT) activation and telomeric DNA sequence restoration.
Overcoming Replicative Senescence: Widely studied in cellular models for extending proliferative lifespan and maintaining genomic stability across multiple cell divisions.
Pineal Axis & Circadian Regulation: Restores pineal gland responsiveness and normalizes nocturnal melatonin secretion patterns in age-degraded endocrine models.
Free Radical Scavenging & Cytoprotection: Demonstrates intrinsic antioxidant capacity, reducing lipid peroxidation and protecting nuclear DNA against oxidative strand breaks.
Analytical Grade Purity (≥99%): Independently batch-tested via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee high experimental repeatability.
Primary Applications in Laboratory Research
Telomere Dynamics & Chromosomal Stability: Investigating TERT gene expression, telomere length kinetics, and chromosomal aberration reduction in vitro.
Endocrine & Pineal Function Restoration: Studying the regulation of gonadotropins, hypothalamic sensitivity, and circadian melatonin bio-synthesis.
Cellular Longevity & Anti-Senescence Protocols: Researching the suppression of senescence-associated secretory phenotype (SASP) markers and cell cycle arrest.
Antioxidant & Enzymatic Defense Systems: Evaluating the upregulation of endogenous antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase.
Product Specifications
Attribute | Specification |
Active Compound | Epithalon (Epitalon / Tetrapeptide Epithalamin) |
Net Quantity | 10 mg |
Form | Lyophilized White Powder |
CAS Number | 307297-39-8 |
Molecular Mass | ~390.35 g/mol |
Sequence | Ala-Glu-Asp-Gly |
Purity Standard | ≥99% (HPLC verified) |
Solubility | Soluble in Bacteriostatic Water, PBS, or Sterile Deionized Water |
Storage & Handling Protocols
Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat, light, and humidity.
Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water or PBS) and utilize within 30 days. Avoid repeated freeze-thaw cycles.
Mandatory Research & Legal Disclaimer
FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, cosmetic application, or commercial drug formulation.