CJC-1295 with DAC 5mg
Long-Acting GHRH Analogue / Extended Somatotropic Standard
$75.00$55.00
Grade: Research Grade / Analytical Standard
Purity: ≥99% (HPLC Verified)
Format: Lyophilized (Freeze-Dried) Powder
Unit Size: 5 mg
Product Overview
CJC-1295 with DAC 5mg (Drug Affinity Complex) is a synthetic 30-amino acid tetrasubstituted peptide analogue of Growth Hormone-Releasing Hormone (GHRH) engineered for extended biological half-life. By incorporating a lysine-linked Drug Affinity Complex (DAC) moiety at the C-terminus, CJC-1295 covalently binds to circulating serum albumin following reconstitution and administration in research models. This bio-conjugation shields the molecule from rapid renal clearance and enzymatic degradation by dipeptidyl peptidase-4 (DPP-IV).
Unlike "No DAC" variants that produce short, transient pulses, CJC-1295 with DAC extends the operational half-life from minutes to approximately 6–8 days. This provides research laboratories with an essential standard for evaluating continuous, baseline growth hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) elevation in long-term endocrine and metabolic protocols.
Key Research Features & Highlights
Covalent Albumin Binding (DAC Technology): Employs Drug Affinity Complex technology to bind serum albumin, extending compound half-life to several days for sustained receptor activation.
Continuous GH & IGF-1 Upregulation: Maintains steady, elevated baseline levels of growth hormone and downstream IGF-1 without requiring frequent re-dosing protocols.
Tetrasubstituted Structural Protection: Features amino acid modifications at positions 2, 8, 15, and 27 that resist DPP-IV peptidase cleavage, ensuring optimal structural integrity in serum.
Pituitary Somatotroph Targeting: Acts as a potent agonist at pituitary GHRH receptors, stimulating endogenous growth hormone synthesis and secretion.
Analytical Grade Purity (≥99%): Independently batch-tested via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee high experimental repeatability.
Primary Applications in Laboratory Research
Extended Somatotropic Axis Kinetics: Investigating prolonged GHRH receptor stimulation, receptor down-regulation dynamics, and continuous pituitary hormone clearance.
Systemic Anabolic & Protein Translation Pathways: Studying long-term Akt/mTOR activation, nitrogen balance retention, and cellular hypertrophic adaptations in muscle tissue models.
Adipocyte Lipolysis & Visceral Fat Metabolism: Researching sustained lipid mobilization, fatty acid oxidation acceleration, and chronic metabolic rate shifts.
Connective Tissue & Skeletal Remodeling: Evaluating long-term extracellular matrix synthesis, collagen cross-linking, and bone density turnover.
Product Specifications
Attribute | Specification |
Active Compound | CJC-1295 with DAC (Tetrasubstituted GHRH + Drug Affinity Complex) |
Net Quantity | 5 mg |
Form | Lyophilized White Powder |
CAS Number | 863288-34-0 (Base) / 448944-47-6 (with DAC) |
Molecular Mass | ~3647.28 g/mol |
Purity Standard | ≥99% (HPLC verified) |
Solubility | Soluble in Bacteriostatic Water or Sterile Deionized Water |
Storage & Handling Protocols
Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from thermal fluctuations, light, and humidity.
Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water) and utilize within 30 days. Avoid repeated freeze-thaw cycles.
Mandatory Research & Legal Disclaimer
FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, or commercial drug formulation.