AOD-9604 5mg
C-Terminal hGH Fragment (177-191) / Lipolytic Research Standard
$49.99$39.99
Grade: Research Grade / Analytical Standard
Purity: ≥99% (HPLC Verified)
Format: Lyophilized (Freeze-Dried) Powder
Unit Size: 5 mg
Product Overview
AOD-9604 5mg (Advanced Obesity Drug-9604) is a modified synthetic 16-amino acid C-terminal peptide fragment (hGH 177-191) derived from human growth hormone, featuring a stabilizing disulfide bridge between Cys182 and Cys189. Engineered specifically to isolate the lipolytic region of the growth hormone molecule, AOD-9604 reproduces the potent lipid-mobilizing capabilities of native hGH without triggering diabetogenic secondary effects, such as IGF-1 elevation, systemic insulin resistance, or altered carbohydrate metabolism.
In cellular and metabolic research, AOD-9604 serves as a primary reference tool for evaluating beta-3 adrenergic receptor signaling, adipocyte lipolysis acceleration, and inhibition of lipogenesis (new fat accumulation) in cultured tissue models.
Key Research Features & Highlights
Targeted Lipolytic Action: Isolates the fat-reducing domain of hGH to stimulate beta-3 adrenergic receptor-mediated lipolysis without affecting systemic growth pathways.
Non-Diabetogenic Metabolic Profile: Demonstrates no adverse impact on baseline blood glucose regulation, insulin sensitivity, or serum IGF-1 levels in laboratory trials.
Dual Action on Fat Metabolism: Simultaneously studied for accelerating β-oxidation of stored triglycerides and inhibiting the enzymatic formation of new lipids (lipogenesis).
Cartilage & Regenerative Potential: Frequently investigated in regenerative biology for promoting chondrocyte differentiation and cartilage matrix maintenance.
Analytical Grade Purity (≥99%): Independently batch-tested via High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure baseline consistency and reproducible experimental outputs.
Primary Applications in Laboratory Research
Adipocyte Lipolysis Kinetics: Investigating intracellular cAMP accumulation, hormone-sensitive lipase (HSL) activation, and free fatty acid liberation in white adipose tissue cell lines.
Lipogenesis Inhibition Mechanisms: Studying the down-regulation of lipogenic enzymes and suppression of pre-adipocyte differentiation.
Skeletal & Joint Tissue Regeneration: Evaluating chondrogenic differentiation, extracellular matrix collagen deposition, and joint repair pathways in vitro.
Comparative Hormonal Signaling: Researching the isolated C-terminal hGH receptor binding kinetics versus full-length recombinant growth hormone.
Product Specifications
Attribute | Specification |
Active Compound | AOD-9604 (Tyr-hGH 177-191 Disulfide Bridge) |
Net Quantity | 5 mg |
Form | Lyophilized White Powder |
CAS Number | 221231-10-3 |
Molecular Mass | ~1815.10 g/mol |
Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (Disulfide bridge Cys7-Cys14) |
Purity Standard | ≥99% (HPLC verified) |
Solubility | Soluble in Bacteriostatic Water or Sterile Deionized Water |
Storage & Handling Protocols
Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat, light, and thermal fluctuations.
Reconstituted Solution: Maintain at 2°C – 8°C following dilution with sterile solvent (e.g., Bacteriostatic Water) and utilize within 30 days. Avoid repeated freeze-thaw cycles.
Mandatory Research & Legal Disclaimer
FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, cosmetic application, or commercial drug formulation.