5-Amino-1MQ 50mg
Selective NNMT Inhibitor / Metabolic Regulator
$199.99$175.00
Grade: Research Grade / Analytical Standard
Purity: ≥99% (HPLC Verified)
Format: Lyophilized (Freeze-Dried) Powder
Unit Size: 50 mg
Product Overview
5-Amino-1MQ 50mg (5-Amino-1-methylquinolinium) is a high-yield small-molecule membrane-permeable compound engineered for extensive laboratory research into cellular energy dynamics and metabolic signaling pathways. It acts as a selective inhibitor of Nicotinamide N-Methyltransferase (NNMT)—a master regulatory enzyme involved in cellular NAD+ homeostasis, histone methylation, and lipid storage.
This high-capacity 50mg format is tailored for research facilities, institutional suppliers, and core laboratories conducting multi-run cellular assays, long-term metabolic flux studies, and high-throughput screening protocols.
Key Research Features & Highlights
High-Capacity 50mg Unit: Provides substantial compound volume for high-throughput screening, multi-target assays, and long-term research protocols.
Targeted NNMT Inhibition: Prevents the degradation of S-adenosylmethionine (SAM) and maintains intracellular NAD+ concentrations within metabolic tissue models.
Adipocyte & Bioenergetic Focus: Serves as a primary reference tool for analyzing rate-limiting metabolic pathways, lipolysis enhancement, and cellular energy expenditure.
Analytical Grade Purity (≥99%): Independently validated through High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to guarantee high experimental reproducibility.
Primary Applications in Laboratory Research
NAD+ Salvage Pathway Kinetics: Evaluating NNMT blockade effects on intracellular NAD+ pool maintenance and sirtuin (SIRT1) activity.
Adipose Tissue & Lipid Remodeling: Investigating adipocyte hypertrophy, lipid droplet turnover, and mitochondrial respiration rates in fat cell models.
Epigenetic & Methylation Modulation: Researching SAM/SAH ratio maintenance and histone methylation changes in aging or stressed cellular environments.
Skeletal Muscle & Bioenergetics: Analyzing glucose uptake, insulin sensitivity signaling, and aerobic capacity adaptations in vitro.
Product Specifications
Attribute | Specification |
Active Compound | 5-Amino-1-methylquinolinium (5-Amino-1MQ) |
Net Quantity | 50 mg |
Form | Lyophilized White/Off-White Powder |
CAS Number | 42464-96-0 |
Molecular Mass | ~159.21 g/mol |
Chemical Formula | C₁₀H₁₁N₂⁺ |
Purity Standard | ≥99% (HPLC verified) |
Solubility | Soluble in DMSO, Water, or specialized research solvents |
Storage & Handling Protocols
Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from heat and moisture.
Reconstituted Solution: Keep refrigerated at 2°C – 8°C following solvent addition and utilize within research protocol parameters. Avoid repeated freeze-thaw cycles.
Mandatory Research & Legal Disclaimer
FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory applications. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, or commercial drug formulation.