5-Amino-1MQ 10mg
NNMT Inhibitor / Metabolic Regulator
$55.00$35.00
Grade: Research Grade / Analytical Standard
Purity: ≥99% (HPLC Verified)
Format: Lyophilized (Freeze-Dried) Powder
Unit Size: 10 mg
Product Overview
5-Amino-1MQ 10mg (5-Amino-1-methylquinolinium) is a small-molecule membrane-permeable compound engineered for scientific investigation into intracellular energy homeostasis and metabolic regulation. It functions as a selective inhibitor of Nicotinamide N-Methyltransferase (NNMT), an enzyme predominantly expressed in adipose tissue and liver cells that plays a central role in NAD+ metabolism and cellular energy flux.
This 10mg format provides research laboratories with an optimal volume for conducting precise cellular assays, NAD+ salvage pathway evaluations, and adipocyte metabolic kinetics studies.
Key Research Features & Highlights
Selective NNMT Inhibition: Blocks NNMT activity to prevent the depletion of S-adenosylmethionine (SAM) and maintain intracellular NAD+ concentrations.
Adipocyte Bioenergetics Focus: Widely studied for its role in enhancing basal metabolic rate, promoting lipolysis, and reducing lipid accumulation in cell models.
High-Purity Standard (≥99%): Batch-tested using High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to ensure baseline consistency and experimental accuracy.
Lyophilized Stabilization: Processed via freeze-drying to preserve chemical stability and extend shelf life prior to laboratory reconstitution.
Primary Applications in Laboratory Research
NAD+ Metabolism & Salvage Pathways: Investigating NNMT blockade effects on cellular NAD+ replenishment and sirtuin (SIRT1) enzyme activation.
Adipose Tissue Remodeling: Studying adipocyte hypertrophy, lipid turnover, and intracellular energy expenditure mechanisms.
Metabolic & Obesity Signaling: Evaluating gene pathways involved in insulin sensitivity, glucose uptake, and thermogenesis in skeletal muscle and fat cells.
Cellular Senescence & Longevity: Analyzing epigenetic regulation via histone methylation maintenance in aging cell models.
Product Specifications
Attribute | Specification |
Active Compound | 5-Amino-1-methylquinolinium (5-Amino-1MQ) |
Net Quantity | 10 mg |
Form | Lyophilized White/Off-White Powder |
CAS Number | 42464-96-0 |
Molecular Mass | ~159.21 g/mol |
Chemical Formula | C₁₀H₁₁N₂⁺ |
Purity Standard | ≥99% (HPLC verified) |
Solubility | Soluble in DMSO, Water, or specialized research solvents |
Storage & Handling Protocols
Unreconstituted (Lyophilized): Store frozen at or below -20°C in a dry, dark environment protected from direct light exposure and humidity.
Reconstituted Solution: Maintain at 2°C – 8°C following solvent addition and utilize within research protocol timelines. Avoid repeated freeze-thaw cycles.
Mandatory Research & Legal Disclaimer
FOR LABORATORY RESEARCH USE ONLY. This compound is distributed exclusively for in vitro scientific research, educational, and analytical laboratory application. It is not approved for human or animal consumption, medical therapy, diagnostic procedures, or commercial drug formulation.